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KMID : 0931320150150030147
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대한상부위장관.헬리코박터학회지
2015 Volume.15 No. 3 p.147 ~ p.154
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Current Trends of Helicobacter pylori Eradication in Korea
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최기돈:Choi Kee-Don
저자없음:No authors listed
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Abstract
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Helicobacter pylori infection is associated with an increased risk of upper gastrointestinal diseases, such as peptic ulcer disease, gastric cancer, and mucosa associated lymphoid tissue lymphoma. Since 1998, when regimens for H. pylori eradication were first recommended in Korea, the triple therapy of proton pump inhibitor, clarithromycin, and amoxicillin has been recommended as a primary regimen. Recently updated Korean guideline also recommends standard triple therapy as first-line regimen. Several studies have suggested that the effectiveness of the standard triple therapy based on clarithromycin has decreased over time. A recent meta-analysis of first-line triple therapy in Korea showed that the eradication rate decreased significantly from 1998 to 2013 (P＜0.001 for both intention-to-treat and per-protocol analyses. The overall eradication rate were 74.6% (95% CI, 72.1∼77.2%) by intention-to-treat analysis and 82.0% (95% CI, 80.8∼83.2%) by per-protocol analysis. Alternative regimens (non-bismuth quadruple therapy; sequential or concomitant therapy, bismuth quadruple therapy, or levofloxacin containing quadruple therapy) can be considered as first-line therapy for H. pylori infection in Korea. Nation-wide surveillance data on the resistance pattern is needed to recommend an effective first-line regimen in Korea.
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KEYWORD
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Helicobacter pylori, Therapeutics, Korea
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